ARG-PRO-PRO-GLY-PHE-SER-PRO-LEU synthesis
- Product Name:ARG-PRO-PRO-GLY-PHE-SER-PRO-LEU
- CAS Number:64695-06-3
- Molecular formula:C41H63N11O10
- Molecular Weight:870.01
29022-11-5
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35661-60-0
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71989-31-6
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35661-40-6
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73724-45-5
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91000-69-0
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64695-06-3
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Yield:-
Reaction Conditions:
Stage #1: Fmoc-Leu-OHwith benzotriazol-1-ol;O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate;N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide at 20; for 1 h;
Stage #2: with piperidine in N,N-dimethyl-formamide at 20; for 0.333333 h;
Stage #3: N-(fluoren-9-ylmethoxycarbonyl)glycine;Fmoc-Pro-OH;N-Fmoc L-Phe;N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine;Fmoc-L-Arg-OHFurther stages;
References:
Lee, Yeon Sun;Muthu, Dhanasekaran;Hall, Sara M.;Ramos-Colon, Cyf;Rankin, David;Hu, Jackie;Sandweiss, Alexander J.;De Felice, Milena;Xie, Jennifer Yanhua;Vanderah, Todd W.;Porreca, Frank;Lai, Josephine;Hruby, Victor J. [Journal of the American Chemical Society,2014,vol. 136,# 18,p. 6608 - 6616]