Artesunate synthesis
- Product Name:Artesunate
- CAS Number:88495-63-0
- Molecular formula:C19H28O8
- Molecular Weight:384.42
A simplified and scalable synthesis of artesunate
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88495-63-0
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$5.00/50mg
Yield:88495-63-0 97%
Reaction Conditions:
with dmap in 1,2-dichloro-ethane at 45; for 6 h;Industrial scale;Reagent/catalyst;Solvent;Temperature;
Steps:
1
Weigh 5 kg of dihydroartemisininIn the jacketed stainless steel reactor R1,Adding 50.0 L dichloroethane,Room temperature stirring dissolved,To prepare a solution; weigh the succinic anhydride 10kg in a jacketed stainless steel reactor R2, add 40.0L dichloroethane, add 50g DMAP, stirring at room temperature, made of solution;The solution in the reactor R1 was added dropwise to the reactor R2 for 4 hours and the mixture was stirred for 2 hours. The pH of the reaction solution was adjusted to 5 with hydrochloric acid and concentrated to a solvent-free solution. 25L dichloroethane and 25L water, stirring extraction, liquid separation, 25L dichloroethane repeated extraction time;The organic phases were combined, dried over anhydrous sodium sulfate, fine filtered, concentrated under reduced pressure,Artesunate 6.56 kg,Yield 97.0%HPLC detection purity 99.9%
References:
CN106946904,2017,A Location in patent:Paragraph 0030; 0031
108-30-5
629 suppliers
$5.00/25g
63968-64-9
613 suppliers
$5.00/250mg
88495-63-0
568 suppliers
$5.00/50mg
108-30-5
629 suppliers
$5.00/25g
71939-50-9
380 suppliers
$5.00/50mg
88495-63-0
568 suppliers
$5.00/50mg
71939-50-9
380 suppliers
$5.00/50mg
88495-63-0
568 suppliers
$5.00/50mg