Atropic acid synthesis
- Product Name:Atropic acid
- CAS Number:492-38-6
- Molecular formula:C9H8O2
- Molecular Weight:148.16
124-38-9
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536-74-3
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$10.00/1g
492-38-6
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$10.00/1g
Yield:492-38-6 82%
Reaction Conditions:
with tetrakis(triphenylphosphine) palladium(0);phenylsilane;2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;triethylamine in N,N-dimethyl-formamide at 80; under 15001.5 Torr; for 12 h;Autoclave;
Steps:
1 Example 1
In the autoclave, Add 0.6 millimoles of phenylacetylene, 0.009 mmol tetrakis (triphenylphosphine)palladium 0.009 mmol 2,2'-bis(diphenylphosphino)-1,1'-binaphthalene, 0.6 millimoles of triethylamine, 0.78 millimoles of phenylsilane and 3 milliliters of N,N-dimethylformamide, Pass 2 MPa carbon dioxide gas, Stir and react for 12 hours at 80 °C, Stop heating and stirring, cool to room temperature, and slowly vent unreacted CO2. The reaction solution was acidified with 3 ml of 2M hydrochloric acid, Wash with water, extract with ethyl acetate, combine the organic phases, use anhydrous magnesium sulfate to dry, filter, remove the solvent by rotary evaporation under reduced pressure, and then separate and purify by column chromatography. get the target product, the column chromatography eluent used is a mixture of petroleum ether: ethyl acetate with a volume ratio of 2:1. the yield was 82percent.
References:
South China University of Technology;Jiang Huanfeng;Xiong Wenfang;Qi Chaorong;Cheng Ruixiang;Wang Lu;Wu Wanqing CN111039773, 2020, A Location in patent:Paragraph 0039-0045
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98-81-7
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492-38-6
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$10.00/1g
124-38-9
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14900-39-1
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$13.00/100mg
492-38-6
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22286-82-4
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492-38-6
246 suppliers
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