ChemicalBook CAS DataBase List AUREUSIDIN

AUREUSIDIN synthesis

5synthesis methods

Product Name:AUREUSIDIN
CAS Number:480-70-6
Molecular formula:C15H10O6
Molecular Weight:286.24

3(2H)-Benzofuranone, 2-[(3,4-dimethoxyphenyl)methylene]-4,6-dimethoxy-

23053-69-2
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480-70-6
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Yield:480-70-6 67.4%

Reaction Conditions:

with boron tribromide in dichloromethane at 0 - 20; for 24 h;Inert atmosphere;

Steps:

18.d

d. Weigh the 4,6,3',4'-tetramethoxyaurone 5r 1mmol obtained in step cAdd it to a 50ml reaction eggplant bottle that has been operated with anhydrous and oxygen-free operation in advance,Add dichloromethane 5m under stirring at 0°C),Slowly add 6mmol of a dichloromethane solution of boron tribromide and stir at 0°C for 1 hour.Warm up naturally to room temperature and continue to stir for 23 hours. TLC detects that the reaction is complete. Then the reaction solution is poured into 18ml ice methanol, adsorbed on activated carbon for 30min, filtered with suction, and concentrated in vacuo. The eluent is methanol: water with a concentration of 30%-40%. Flash carbon 18 column purification,The final product 4,6,3',4'-tetrahydroxyaurone 6r was obtained with a yield of 67.4%;

References:

CN113105417,2021,A Location in patent:Paragraph 0159-0160; 0164-0165

120-14-9 Synthesis