azetidine-3,3-diyldimethanol synthesis

3synthesis methods

Product Name:azetidine-3,3-diyldimethanol
CAS Number:45512-27-4
Molecular formula:C5H11NO2
Molecular Weight:117.15

26096-30-0
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45512-27-4
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Yield:-

Reaction Conditions:

with hydrogen;palladium(II) hydroxide/carbon in methanol at 20;

Steps:

1

Azetidine-3,3-dimethanol hydrochloride (5). Pd(OH)₂ (20% on C, 150 mg, 1.9 mmol) was added to a solution of 4 (400 mg, 1.9 mmol) in MeOH (4 mL) and left to stir under an atmosphere of hydrogen overnight at room temperature. The reaction was filtered through Celite and concentrated in vacuo. Chromatography (1 ,4-dioxane/NH4θH = 50:50) of the resulting residue afforded 5 as a colourless oil which was converted to its HCI salt (200 mg, 68%) for characterisation. ¹H NMR (D₂O): δ 3.97 (s, 4H), 3.69 (s, 4H). ¹³C NMR (D₂O): δ 62.4, 49.8.

References:

WO2008/79028,2008,A1 Location in patent:Page/Page column 15-16

22633-44-9 Synthesis

22633-44-9
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References

3,3-Azetidinedicarboxylic acid, 1-(phenylmethyl)-, 3,3-diethyl ester

642411-11-8
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$55.00/50mg

45512-27-4
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References