BECLOTIAMINE synthesis

Yield:13471-78-8 5.7 g

Reaction Conditions:

with thionyl chloride in toluene; for 1 h;Reflux;

Steps:

1

Take 10.0g thiamine hydrochloride into the reaction flask,Add 100ml of toluene, 6.3g of thionyl chloride,Stir and heat to reflux for 1 hour,Cool down to room temperature, filter,The obtained solid was passed through a silica gel column, washed with methanol/dichloromethane=1:5,5.7g of intermediate V was obtained.

References:

CN112778367,2021,A Location in patent:Paragraph 0027-0029