Benzaldehyde, 2-amino-6-(trifluoromethyl)- synthesis
- Product Name:Benzaldehyde, 2-amino-6-(trifluoromethyl)-
- CAS Number:1289209-47-7
- Molecular formula:C8H6F3NO
- Molecular Weight:189.13
763027-00-5
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Yield:1289209-47-7 88%
Reaction Conditions:
with manganese(IV) oxide in dichloromethane at 20; for 23 h;Inert atmosphere;
Steps:
95 6,7-Didehydro-17-methyl-5'-trifluoromethylquinolino[2',3':6,7]morphinan-3,14β-diol (28a)
5.1.95
6,7-Didehydro-17-methyl-5'-trifluoromethylquinolino[2',3':6,7]morphinan-3,14β-diol hydrochloride (SYK-338)
SYK-338 was prepared from compound 28a according to the procedure used to prepare SYK-27.
Yield, quant.; a white amorphous solid.
Mp 234-238 °C (dec). Anal. Calcd for C25H23F3N2O2·1.3HCl·0.9H2O: C, 59.57; H, 5.22; N, 5.56. Found: C, 59.68; H, 5.50; N, 5.53.
References:
Ida, Yoshihiro;Matsubara, Ayaka;Nemoto, Toru;Saito, Manabu;Hirayama, Shigeto;Fujii, Hideaki;Nagase, Hiroshi [Bioorganic and Medicinal Chemistry,2012,vol. 20,# 19,p. 5810 - 5831]
314-46-5
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