Benzaldehyde, 2-fluoro-4-hydroxy-5-methoxy- synthesis
- Product Name:Benzaldehyde, 2-fluoro-4-hydroxy-5-methoxy-
- CAS Number:79418-77-2
- Molecular formula:C8H7FO3
- Molecular Weight:170.14
71924-62-4
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Yield:79418-77-2 76%
Reaction Conditions:
with aluminum (III) chloride in dichloromethane at 20;
Steps:
1
2-Fluoro-4-hydroxy-5-methoxy-benzaldehyde 39 was synthesized in one step from 2-fluoro- 4,5-dimethoxy-benzaldehyde 38 as shown in Scheme 8.Scheme 8Step 1 - Synthesis of2-fluoro-4-hydroxy-5-methoxy-benzaldehyde (39):[0180] To 2-fluoro-4.5-dimethoxy-benzaldehyde (38, 1.00 g, 5.43 mol) in dichloromethane (50.0 mL) was added aluminum trichloride (4.34 g, 32.6 mmol) under an atmosphere of nitrogen. The reaction was stirred at room temperature overnight. The reaction was poured into water and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated and washed with ethyl acetate and hexane to give a white solid (39, 0.7Og,76.0%).
References:
WO2008/79909,2008,A1 Location in patent:Page/Page column 80
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