Benzaldehyde, 2-fluoro-6-(trifluoromethyl)-, oxime synthesis

Yield:581072-15-3 95.2%

Reaction Conditions:

with hydroxylamine hydrochloride;sodium acetate;sodium hydroxide in ethanol;water at 80 - 85;Temperature;Solvent;

Steps:

1.2 1.2 Synthesis of Intermediate B

In a 3L three-neck flask, intermediate A (192.0 g, 1 -Omol), ethanol (500 ml), NH20H.HC1 (82.8 g, 1.2 mol), Na0H (48 g, 1.2 mol), Na0Ac (163.3 g, 1,5 mol) And Η2Ο (200ml). Then it is heated to 80-85°C and reacted for 20-24 hours at this temperature, after which it is cooled to room temperature. The organic solvent was concentrated, a large amount of solid precipitated out, and the filter cake was washed with H20 (200 ml X 2). It was dried to give a solid, 197.lg, with a yield of 95.2%.

References:

CN107935863,2018,A Location in patent:Paragraph 0043-0047; 0055-0056; 0062-0063