Benzaldehyde, 2-nitro-4-(trifluoromethyl)-, oxime synthesis
- Product Name:Benzaldehyde, 2-nitro-4-(trifluoromethyl)-, oxime
- CAS Number:109466-86-6
- Molecular formula:C8H5F3N2O3
- Molecular Weight:234.13
109466-87-7
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Yield:109466-86-6 88%
Reaction Conditions:
with hydroxylamine hydrochloride;sodium hydroxide in water at 8 - 20;Large scale;Temperature;
Steps:
1.1; 2.1; 3.1; 4.1 Example 3
First step: adding 4.4 kg of 2-nitro-4-trifluoromethylbenzaldehyde and 13 kg of water to the reaction kettle.Add 1.4kg of hydroxylamine hydrochloride and start stirring.Add 3.2 kg of 50% sodium hydroxide at 8-20 ° C, after the reaction is completed,Neutralize with hydrochloric acid to pH = 7, extract three times with diethyl ether, and concentrate the extract.2-Nitro-4-trifluoromethylbenzaldehyde oxime was obtained, and after drying, a solid was obtained, 4.1 kg, yield: 88%.
References:
CN109438282,2019,A Location in patent:Page/Page column 4-6
