ChemicalBook CAS DataBase List BenzaMide, 3-nitro-N-(phenylMethyl)-

BenzaMide, 3-nitro-N-(phenylMethyl)- synthesis

10synthesis methods

Product Name:BenzaMide, 3-nitro-N-(phenylMethyl)-
CAS Number:7595-68-8
Molecular formula:C14H12N2O3
Molecular Weight:256.26

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Yield: 90%

Reaction Conditions:

with Ce(III) immobilised on an aminated epichlorohydrin-activated agarose matrix at 140; for 4 h;Green chemistry;

Steps:

General procedure for transamidation of benzamide with benzylamine using CAEA and recovery of CAEA
General procedure: CAEA (0.01 g) was added to a mixture of benzamide (1 mmol, 0.121 g) and benzylamine (1.1 mmol, 0.117 g) in a round-bottom flask equipped with a condenser under solvent-free conditions. The reaction mixture was stirred (250 min^-1) at 140 °C. The progress of the reaction was monitored by TLC. Following the reaction, the reaction mixture was cooled and the resultant mixture was submitted to silica gel preparative TLC using ethyl acetate/hexane (1/1) as eluent. N-Benzylbenzamide was obtained with a 95 % yield (0.198 g). The spectral data of the compounds are given in Tables 1 and 2. The reaction mixture was centrifuged (1000 min^-1,10 min) and washed several times with ethyl acetate and acetone to remove all the organic compounds then the precipitate was dried at ambient temperature.

References:

Zarei, Zeinab;Akhlaghinia, Batool [Chemical Papers,2015,vol. 69,# 11,p. 1421 - 1437]

100-46-9 Synthesis

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