Benzamide, 4-(cyanomethyl)- (9CI) synthesis

Yield:114365-07-0 77%

Reaction Conditions:

with water extract of pomelo, peel at 150; for 0.5 h;Sealed tube;Green chemistry;

Steps:

3.3. General Procedure for the Hydrolysis of Nitriles in WEPPA (Taking 1a as an Example

General procedure: Benzonitrile 1a (103 mg, 1.0 mmol) and WEPPA (2.0 mL) were added into a 10-mL closed tubewith a stir bar. Then the reaction was stirred in a closed vessel synthesis reactor at 150 C for 0.5 h.After cooling to ambient temperature, the resulting precipitate was collected by filtration, washed withice water, and further dried in a vacuum drying oven. The filtrate was evaporated under reducedpressure. The resultant residue was purified by silica gel column chromatography (eluent: petroleumether (35-60 C)/EtOAc = 2:1 to 0:1, v/v). Finally, these two parts were combined to produce the desiredbenzamide 2a with a 94% yield.

References:

Sun, Yajun;Jin, Weiwei;Liu, Chenjiang [Molecules,2019,vol. 24,# 21,art. no. 3838] Location in patent:supporting information