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Benzenamine, 2-ethyl-6-propyl- synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: 25 percent / Et3N / tetrahydrofuran / Heating
2: 73 percent / Na2CO3 / ethanol; H2O / 20 °C
3: ZnCl2 / o-xylene / Heating
4: H2 / 10 percent Pd/C / acetic acid / 3 h / 20 °C

References:

Von Geldern, Thomas W.;Tasker, Andrew S.;Sorensen, Bryan K.;Winn, Martin;Szczepankiewicz, Bruce G.;Dixon, Douglas B.;Chiou, William J.;Wang, Liming;Wessale, Jerry L.;Adler, Andy;Marsh, Kennan C.;Nguyen, Bach;Opgenorth, Terry J. [Journal of Medicinal Chemistry,1999,vol. 42,# 18,p. 3668 - 3678]