![](/CAS/20150408/GIF/190728-25-7.gif)
4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline synthesis
- Product Name:4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline
- CAS Number:190728-25-7
- Molecular formula:C17H16N2O3
- Molecular Weight:296.32
![4-chloro-6,7-dimethoxyquinoline](/CAS/GIF/35654-56-9.gif)
35654-56-9
340 suppliers
$13.00/1g
![4-Aminophenol](/CAS/GIF/123-30-8.gif)
123-30-8
606 suppliers
$10.00/5g
![4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline](/CAS/20150408/GIF/190728-25-7.gif)
190728-25-7
199 suppliers
$11.00/250mg
Yield:190728-25-7 90%
Reaction Conditions:
with sodium t-butanolate in N,N-dimethyl acetamide at -5 - 110;
Steps:
1; 2 Example 1 Preparation of Compound (II)
The compound (I) (500 g, 2.23 µM), 4-aminophenol (345 g, 3.16 µM) are added to a reaction in the bottle, adding DMA (3 L), lowering the temperature to 0 °C -5 °C, drop which is in butanol sodium (430 g) of DMA (2 L) suspension, then completing, heating up to 100 °C -110 °C, thermal insulation reaction 4 - 5 hours. (TLC monitoring the reaction is complete, Rf value 0.4 (dichloromethane: methanol=20:1)). Lowering the temperature to -5 °C -0 °C, adding ice water (10 L), stirring crystallization 15 - 16 hours. Filtering, cake a little water to wash, for 50 °C drying by blowing 15 - 16 hours to obtain light yellow solid 595 g, yield 90%, HPLC purity 99.7%
References:
Jiangsu Haosen Pharmaceutical Group Co., Ltd.;Fan Xingbao;Zhang Liang;Chen Anfeng;Zhou Bingcheng CN109836382, 2019, A Location in patent:Paragraph 0072-0077
![Quinoline, 6,7-dimethoxy-4-(4-nitrophenoxy)-](/CAS/20180629/GIF/190728-24-6.gif)
190728-24-6
28 suppliers
inquiry
![4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline](/CAS/20150408/GIF/190728-25-7.gif)
190728-25-7
199 suppliers
$11.00/250mg
![4-chloro-6,7-dimethoxyquinoline](/CAS/GIF/35654-56-9.gif)
35654-56-9
340 suppliers
$13.00/1g
![4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline](/CAS/20150408/GIF/190728-25-7.gif)
190728-25-7
199 suppliers
$11.00/250mg
![2'-AMINO-4',5'-DIMETHOXYACETOPHENONE](/CAS/GIF/4101-30-8.gif)
4101-30-8
131 suppliers
$7.00/250mg
![4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline](/CAS/20150408/GIF/190728-25-7.gif)
190728-25-7
199 suppliers
$11.00/250mg
![4-Aminoveratrole](/CAS/GIF/6315-89-5.gif)
6315-89-5
302 suppliers
$7.00/10g
![4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline](/CAS/20150408/GIF/190728-25-7.gif)
190728-25-7
199 suppliers
$11.00/250mg