Benzenamine,4-(9,9-dimethyl-9H-fluoren-2-yl)- synthesis

5synthesis methods

Product Name:Benzenamine,4-(9,9-dimethyl-9H-fluoren-2-yl)-
CAS Number:1221237-85-9
Molecular formula:C21H19N
Molecular Weight:285.38

106-40-1 Synthesis

106-40-1
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333432-28-3 Synthesis

9,9-Dimethyl-9H-fluoren-2-yl-boronic acid

333432-28-3
225 suppliers
$18.60/250mg

Benzenamine,4-(9,9-dimethyl-9H-fluoren-2-yl)-

1221237-85-9
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Yield:1221237-85-9 91%

Reaction Conditions:

with potassium carbonate;tetrakis(triphenylphosphine) palladium⁽⁰⁾ in tetrahydrofuran;water; for 5 h;Heating;

Steps:

2

Preparation of Structural Formula 14E; The Structural Formula 14D (10 g, 42.0 mmol), and 4-bromoaniline (6.9 g, 39.9 mmol) were dissolved in 100 ml of tetrahydrofurane, 100 ml of 2M potassium carbonate aqueous solution and PdCPPh₃)₄ (485 mg, 0.42 mmol) were added thereto, and heated and agitated for 5 hours. After the temperature was lowered to normal temperature, the organic layer was extracted, concentrated, and recrystallized with ethanol to obtain the Structural Formula 14E (10.4 g, yield 91%). MS: [M+ H]⁺ = 286

References:

EP2343277,2011,A2 Location in patent:Page/Page column 36

28320-31-2 Synthesis