Benzene, 1-bromo-2-ethenyl-4-(trifluoromethyl)- synthesis

3synthesis methods

Product Name:Benzene, 1-bromo-2-ethenyl-4-(trifluoromethyl)-
CAS Number:1263772-10-6
Molecular formula:C9H6BrF3
Molecular Weight:251.04

402-43-7 Synthesis

402-43-7
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Benzene, 1-bromo-2-ethenyl-4-(trifluoromethyl)-

1263772-10-6
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Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
1.2: 1.08 h / -78 - 20 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / Inert atmosphere; Cooling with ice
2.2: Wittig Olefination / 1 h / 20 °C / Inert atmosphere

References:

Van Hoveln, Ryan;Hudson, Brandi M.;Wedler, Henry B.;Bates, Desiree M.;Le Gros, Gabriel;Tantillo, Dean J.;Schomaker, Jennifer M. [Journal of the American Chemical Society,2015,vol. 137,# 16,p. 5346 - 5354]

1779-49-3
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102684-91-3
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1263772-10-6
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References

2065-66-9
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102684-91-3
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1263772-10-6
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References