Benzene, 1-broMo-3-(MethoxyMethoxy)- synthesis
- Product Name:Benzene, 1-broMo-3-(MethoxyMethoxy)-
- CAS Number:42471-59-0
- Molecular formula:C8H9BrO2
- Molecular Weight:217.06
13057-17-5
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591-20-8
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42471-59-0
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$70.00/250mg
Yield:42471-59-0 38 g
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine in dichloromethane at 0 - 20; for 16 h;
Steps:
42.4 Step 4: Synthesis of 1- bromo-3-(methoxymethoxy)benzene.
Step 4: Synthesis of 1- bromo-3-(methoxymethoxy)benzene. A solution of 3-bromophenol (30 g, 0.17 mol) and DIPEA (33.6 g, 0.26 mol) in DCM (300 mL) stirred at 0oC was treated with dropwise addition of methoxymethyl bromide (27.9 g, 225mmol) and the reaction mixture was further stirred at room temperature for 16 h., washed with water (200 mL x 2), aqueous NH4Cl solution (200 mL) and brine (200mL). The organic layer was dried over Na2SO4, filtered and concentrated to render 1-bromo-3-(methoxy- methoxy)benzene (38 g) as a yellow oil.1HNMR (400 MHz, CDCl3) δ ppm: 7.28-7.22 (m, 2H), 7.20-7.17 (m, 1H), 7.06-7.02 (m, 1H), 5.21 (s, 2H), 3.37 (s, 3H).
References:
WO2016/44641,2016,A2 Location in patent:Paragraph 00445
591-20-8
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107-30-2
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42471-59-0
43 suppliers
$70.00/250mg
591-20-8
338 suppliers
$10.00/1g
3188-13-4
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42471-59-0
43 suppliers
$70.00/250mg