Benzene, 1-(chloroMethyl)-3-(1-Methylethoxy)- synthesis

3synthesis methods

Product Name:Benzene, 1-(chloroMethyl)-3-(1-Methylethoxy)-
CAS Number:26066-16-0
Molecular formula:C10H13ClO
Molecular Weight:184.66

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Benzene, 1-(chloroMethyl)-3-(1-Methylethoxy)-

26066-16-0
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Yield:26066-16-0 64%

Reaction Conditions:

with tetrachloromethane;triphenylphosphineReflux;

Steps:

To a stirred solution of the 3-isopropoxybenzylalcohol (19.5 g, 116 mmole) in carbontetrachloride was added triphenylphosphine(32 g, 122 mmoles) and the mixture was refluxed. The crude reaction was pre-loaded onto silica gel and chromatographed eluting with 10% EtOAc/hexanes to give the product (13.4 g,64%).

References:

Egbertson, Melissa;McGaughey, Georgia B.;Pitzenberger, Steven M.;Stauffer, Shaun R.;Coburn, Craig A.;Stachel, Shawn J.;Yang, Wenjin;Barrow, James C.;Neilson, Lou Anne;McWherter, Melody;Perlow, Debra;Fahr, Bruce;Munshi, Sanjeev;Allison, Timothy J.;Holloway, Katharine;Selnick, Harold G.;Yang, Zhiqiang;Swestock, John;Simon, Adam J.;Sankaranarayanan, Sethu;Colussi, Dennis;Tugusheva, Katherine;Lai, Ming-Tain;Pietrak, Beth;Haugabook, Shari;Jin, Lixia;Chen;Holahan, Marie;Stranieri-Michener, Maria;Cook, Jacquelynn J.;Vacca, Joseph;Graham, Samuel L. [Bioorganic and Medicinal Chemistry Letters,2015,vol. 25,# 21,p. 4812 - 4819] Location in patent:supporting information

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References

75792-33-5
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References