Benzene, 1-cyclohexyl-2-(trifluoromethyl)- synthesis
- Product Name:Benzene, 1-cyclohexyl-2-(trifluoromethyl)-
- CAS Number:13376-27-7
- Molecular formula:C13H15F3
- Molecular Weight:228.25
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Yield:-
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in methanol;water at 40; under 750.075 - 3750.38 Torr;
Steps:
2 Synthesis of 1-cyclohexyl-2-trifluoromethylbenzene
In a hydrogenation reactor 8.45g 1-Cyclohexyl-2-trifluoromethyl-benzene were dissolved in 42ml methanol. 1 .33g Palladium 10% on Charcoal water wet was added and the reaction mixture hydrogenated with hydrogen gas at IT = 40°C and 1 -5 Bar until the uptake of hydrogen stopped. After filtration over Hyflo, the filtrate was evaporated to dryness and degassed. Heptanes (40 ml) were added and the mixture was evaporated to dryness and degassed again. This gave 7.64g 1-cyclohexyl-2-trifluoromethyl-benzene as a slightly turbid yellow oil which was used without further purification for the synthesis of 4-bromo-1-cyclohexyl-2-trifluoromethyl- benzene. 1H-NMR (400MHz, CDCI3): δ 1.35-1 .9(1 OH, m), 2.85-3(1 h,m)7.2-7.3(1 H,m)7.4-7.5(2h,m), 7.55 - 7.65(1 H,m).
References:
WO2013/113915,2013,A1 Location in patent:Page/Page column 27
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