ChemicalBook CAS DataBase List Benzene, 1-ethenyl-2-(1-Methylethoxy)-

Benzene, 1-ethenyl-2-(1-Methylethoxy)- synthesis

5synthesis methods

Product Name:Benzene, 1-ethenyl-2-(1-Methylethoxy)-
CAS Number:67191-35-9
Molecular formula:C11H14O
Molecular Weight:162.23

1779-49-3
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$5.00/10g

22921-58-0
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$42.00/500mg

67191-35-9
43 suppliers
$220.00/500mg

Yield:67191-35-9 3.66 g

Reaction Conditions:

Stage #1:Methyltriphenylphosphonium bromide with n-butyllithium in tetrahydrofuran;hexane at 20; for 4 h;
Stage #2:2-isopropoxybenzaldehyde in tetrahydrofuran;hexane for 1 h;

Steps:

Synthesis of 1-isopropoxy-2-vinylbenzene.
Synthesis of 1-isopropoxy-2-vinylbenzene. A suspension of 15.65 g of methyl triphenylphosphonium bromide in 100 mL of dry THE was treated at room temperature with 19.0 mL of n-BuLi (2.5 M solution in n-hexane). The resulting orange solution was stirred for 4 hours. Then, a solution of 6.00 g (36.5mmol) of 2-isopropoxybenzaldehyde in 25 mL of dry THE was added dropwise. Upon addition, a white precipitate formed. The suspension was stirred for 1 hour and concentrated in vacuo to give a viscous yellow oil that was purified by passing through a short column of Si02 (heptane) then vacuum distillation to yield 3.66 g of 1-isopropoxy-2-vinylbenzene as a colorless liquid. 1H-NMR (300 MHz, CDCI3): 51.27 (d, J=6.1 Hz, 6H), 4.47 (m, 1H), 5.15 (dd, Ji=11.2 Hz, J2=1.6 Hz, 1H), 5.65 (dd, Ji=17.8Hz, J2=1.6 Hz, IH), 6.78-6.88 (m, 2H), 6.92-7.05 (m, 1H), 7.08-7.16 (m, IH), 7.40 (dd, J1=7.6 Hz, J2=1.7 Hz, 1H). GC-MS: >99.0% MS (El): 162.

References:

XIMO AG;TOTH, Florian;FRÁTER, Georg;ONDI, Levente WO2015/155593, 2015, A1 Location in patent:Page/Page column 50

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90-02-8 Synthesis