Benzene, 2,3-difluoro-1-(1-methylethoxy)-4-nitro- synthesis
- Product Name:Benzene, 2,3-difluoro-1-(1-methylethoxy)-4-nitro-
- CAS Number:1416818-76-2
- Molecular formula:C9H9F2NO3
- Molecular Weight:217.17
75-30-9
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Yield:1416818-76-2 48%
Reaction Conditions:
with potassium carbonate in dimethyl sulfoxide at 20 - 50; for 8 h;
Steps:
1.30.b
Step b : 2 , 3 -difluoro - 1 -isopropoxy-4-nitrobenzene[0543] 2-Iodopropane (7.3 g, 42.9 mmol) was added to a mixture of 2,3-difluoro-4-nitrophenol (5.0 g, 28.6 mmol) and K2C03 (8.0 g, 57.0 mmol) in DMSO (20.0 mL) at room temperature. The reaction mixture was stirred at 50°C for 8 h. After the mixture was cooled to room temperature, it was poured into water and the resulting mixture was extracted with ethyl acetate. The combined extracts were washed with brine, dried over anhydrous Na2S04 and concentrated to afford 3.0 g of the title compound as a yellow solid (48% yield).
References:
WO2012/178015,2012,A2 Location in patent:Page/Page column 139
6418-38-8
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