Benzene, 2-bromo-1,3-dichloro-5-nitro- synthesis
- Product Name:Benzene, 2-bromo-1,3-dichloro-5-nitro-
- CAS Number:98137-94-1
- Molecular formula:C6H2BrCl2NO2
- Molecular Weight:270.9
99-30-9
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Yield:98137-94-1 97%
Reaction Conditions:
with tert.-butylnitrite;copper(I) bromide in acetonitrile at 20; for 6 h;Cooling with ice;
Steps:
1 Step 1: 2-bromo-1,3-dichloro-5-nitrobenzene
2,6-dichloro-4-nitroaniline (5 g, 24 mmol), copper bromide (16 g, 72 mmol) and acetonitrile (50 mL) were added to a single-mouth bottle, t-butyl nitrite (7.46 g, 72 mmol) was added dropwise while stirring under ice bath, and then the obtained mixture was subjected to a reaction for 6 hours while stirring at a room temperature. After the reaction, the mixture was added with water (100 mL), extracted with ethyl acetate (100 mL32), washed with saturated sodium chloride (100 mL), dried over anhydrous sodium sulfate, and concentrated at a reduced pressure to give 6.3 g orange solid, with a yield of 97%
References:
EP3476829,2019,A1 Location in patent:Paragraph 0054
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98137-94-1
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