Benzene, (3-bromo-2-propen-1-yl)- synthesis

Yield:-

Reaction Conditions:

with potassium phosphate in ethanol at 80; for 0.166667 h;

Steps:

Synthesis of acetylenes from vicinal dibromides

General procedure: A mixture of vicinal dibromide (5 mmol), anhydrous K₃PO₄ (5 mmol), PEG-900 (1.25 mmol), and EtOH (10 mL) was stirred at 80 °C. The progress of the reaction was monitored by analysis of the samples using TLC and gas chromatography. When the vicinal dibromide had been completely converted into the monobromo product, a second portion of K₃PO₄ (5 mmol) was added.Following completion of the reaction the mixture was filtered and the filtrate was diluted with CH₂Cl and washed several times with H₂O. The organic phase was dried over MgSO₄ and evaporated under vacuum to afford a mixture of product and the monobromo derivative. The acetylene was separated by vacuum distillation. The identity and purity of the products were confirmed by GC-MS and ¹H NMR spectroscopy.

References:

Shenawi-Khalil, Sanaa;Sonavane, Sachin U.;Sasson, Yoel [Tetrahedron Letters,2012,vol. 53,# 18,p. 2295 - 2297] Location in patent:experimental part