ChemicalBook CAS DataBase List Benzenebutanol, 4-bromo-

Benzenebutanol, 4-bromo- synthesis

7synthesis methods

Product Name:Benzenebutanol, 4-bromo-
CAS Number:75906-36-4
Molecular formula:C10H13BrO
Molecular Weight:229.11

35656-89-4 Synthesis

35656-89-4
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75906-36-4
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Yield:75906-36-4 100%

Reaction Conditions:

Stage #1: 4-(4-bromophenyl)butanoic acidwith lithium aluminium tetrahydride in tetrahydrofuran; for 1 h;Cooling with ice;
Stage #2: with water in tetrahydrofuran;acetone;

Steps:

5.21.1

(1) Lithium aluminum hydride (759 mg) was added to a solution of 4-(4-bromophenyl)butyric acid (3.12 g) in tetrahydrofuran (90 mL) under ice-cooling, and the mixture was stirred under ice-cooling for one hour. Acetone and water were added to the reaction solution, followed by extraction with ethyl acetate. The organic layer was dried over sodium sulfate and filtered. The solvent was then evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=30:1→10:1→7:1 5:1) to give 4-(4-bromophenyl)butan-1-ol (2.29 g, quant.).

References:

US2011/237791,2011,A1 Location in patent:Page/Page column 80

35656-89-4 Synthesis

35656-89-4
129 suppliers
$25.00/1g