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BENZENEBUTANOL, 4-METHYL- synthesis

7synthesis methods
-

Yield:53392-07-7 78%

Reaction Conditions:

Stage #1: para-xylenewith 3-(chloromethyl)heptane;N,N,N,N,-tetramethylethylenediamine;natrium in hexane;isopropanol;toluene at 25; for 0.127778 h;Flow reactor;
Stage #2: trimethylene oxide in tetrahydrofuran;hexane;isopropanol;toluene at -20 - 25; for 0.7 h;Flow reactor;

References:

Harenberg, Johannes H.;Reddy Annapureddy, Rajasekar;Karaghiosoff, Konstantin;Knochel, Paul [Angewandte Chemie - International Edition,2022,vol. 61,# 30,art. no. E202203807][Angew. Chem.,2022,vol. 134,# 30] Location in patent:supporting information