ChemicalBook CAS DataBase List Benzeneethanamine, 3,4-difluoro- (9CI)

Benzeneethanamine, 3,4-difluoro- (9CI) synthesis

4synthesis methods

Product Name:Benzeneethanamine, 3,4-difluoro- (9CI)
CAS Number:220362-31-2
Molecular formula:C8H9F2N
Molecular Weight:157.16

1,2-difluoro-4-[(E)-2-nitroethenyl]benzene

1025692-47-0
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220362-31-2
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Yield: 100%

Reaction Conditions:

with lithium borohydride;chloro-trimethyl-silane in tetrahydrofuran at 0 - 20;

Steps:

49 Preparation of Intermediate 2-(3,4-Difluorophenyl)ethanamine (I-49b)
Preparation of Intermediate 2-(3,4-Difluorophenyl)ethanamine (I-49b)
Using an analogous procedure and workup as described in for the preparation of intermediate I-15b above. (E-1,2-difluoro-4-(2-nitrovinyl)benzene (I-49a: 5 g, 27.027 mmol) in dry THF (81 mL) as reacted with LiBH₄ (2.35 g, 108.1081 mmol) and chloro trimethyl silane (27.63 ml, 216.216 mmol) at 0° C.
The resulting mixture was stirred at room temperature for 3 days to afford 4.2 g of the product (100% yield).
¹H NMR (DMSO, 300 MHz): δ 8.7 (bs, 2H), 7.5-7.3 (m, 2H), 7.2-7.0 (m, 1H), 3.0-2.8 (m, 4H). LCMS: 98.87%, m/z=158.1 (M+1)

References:

NOVARTIS AG;Bock, Mark Gary;Gaul, Christoph;Gummadi, Venkateshwar Rao;Moebitz, Henrik;Sengupta, Saumitra US2014/45872, 2014, A1 Location in patent:Paragraph 0814

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220362-31-2
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$90.00/250mg

References

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References

34036-07-2
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220362-31-2
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$90.00/250mg

References