Benzeneethanamine, 4-(difluoromethoxy)-3-methoxy- synthesis
1synthesis methods
- Product Name:Benzeneethanamine, 4-(difluoromethoxy)-3-methoxy-
- CAS Number:823234-68-0
- Molecular formula:C10H13F2NO2
- Molecular Weight:217.21
Yield:-
Steps:
D4
D4. 2-[4-(1 ,1 -Difluoro-methoxy)-3-methoxy-phenyl]-ethylamine; 2-[4-(1 ,1-Difluoro-methoxy)-3-methoxy-phenyl]-ethylamine can be prepared by difluoromethylation of 4-hydroxy-3-methoxy benzaldehyde with chloro difluoro methane according to a procedure published by Amschler et al. (WO97/28131 ), followed by a sequence described by Shepard et al. in J. Org. Chem. 1952, 17, 568. MS (M+H) = 217.6
References:
WO2006/89815,2006,A1 Location in patent:Page/Page column 37