BENZENEETHANIMIDAMIDE, 3-CHLORO-N-HYDROXY- synthesis

Yield:175532-13-5 100%

Reaction Conditions:

with hydroxylamine hydrochloride;sodium in methanol;

Steps:

52.I I.

I. 7-(3-(3-Chlorophenylmethyl)-1,2,4-oxadiaz-5-y))-1-(4-methylpiperazin-1-yl)naphthalene Sodium (0.120 g, 5.2 mol), hydroxylamine hydrochloride (0.35 g, 5.0 mmol), and (3-chlorophenyl)acetonitrile (0.303 g, 2.0 mmol) and methanol (5 mL) were used to prepare (3-chlorophenyl)acetamidoxime (0.42 g, >100%) as described above.

References:

US6166020,2000,A