Benzeneethanol, 2-(chloroMethyl)-, 1-benzoate synthesis
- Product Name:Benzeneethanol, 2-(chloroMethyl)-, 1-benzoate
- CAS Number:168476-58-2
- Molecular formula:C16H15ClO2
- Molecular Weight:274.74
Yield:168476-58-2 100%
Reaction Conditions:
zinc(II) chloride in dichloromethane; for 2 h;Heating / reflux;
Steps:
2,3-Benzopyran (40 g, 300 mmol)) was slowly added with stirring to a mixture of zinc chloride (4.2 g, 31 mmol)) and 4.6 g (330 mmol) of benzoyl chloride in 110 mL of dichloromethane. By the end of the addition the mixture was refluxing. The reaction was refluxed for 2 hours. The mixture was cooled to room temperature and 140 mL of water was added with vigorous stirring. The layers were separated and the aqueous layer discarded. The organic layer was washed with water and then brine. The organic layer was filtered through phase separation paper and rotary evaporated to dryness to give 8.5 g (103% yield) of 2-[2-phenylcarbonyloxy)ethyl]benzyl chloride.
References:
US2004/186160,2004,A1 Location in patent:Page/Page column 22
60-12-8
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