Benzeneethanol, 4-bromo-2-fluoro-, 1-acetate synthesis
- Product Name:Benzeneethanol, 4-bromo-2-fluoro-, 1-acetate
- CAS Number:1426050-14-7
- Molecular formula:C10H10BrFO2
- Molecular Weight:261.09
193290-20-9
20 suppliers
$185.00/250mg
108-24-7
5 suppliers
$14.00/250ML
1426050-14-7
0 suppliers
inquiry
Yield:1426050-14-7 81%
Reaction Conditions:
with pyridine;dmap at 20;
Steps:
25.b b) 4-bromo-2-fluorophenethyl acetate
A solution of 2-(4-bromo-2-fluorophenyl)ethanol (3.01 mmol) in dichloromethane (5 mL) and pyridine (10 mL) was treated with 4-(dimethylamino)pyridine (0.151 mmol) and acetic anhydride (9.04 mmol). The reaction was stirred overnight at room temperature. At this point the reaction was diluted with dichloromethane (100 mL). The organic layer was washed three times with IN aq HC1, once with saturated aq sodium bicarbonate, and once with brine. The organic layer was dried over sodium sulfate, filtered and concentrated in vacuo to afford the title compound as a pale beige oil (710 mg, 81% yield). 1H NMR (400 MHz, DMSO-de) d ppm 1.96 (s, 3 H) 2.90 (t, J=6.44 Hz, 2 H) 4.20 (t, J=6.57 Hz, 2 H) 7.26 - 7.43 (m, 2 H) 7.51 (dd, J=9.73, 1.89 Hz, 1 H).
References:
WO2013/28447,2013,A1 Location in patent:Page/Page column 79
114897-92-6
131 suppliers
$10.00/1g
1426050-14-7
0 suppliers
inquiry