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Benzeneethanol, 4-bromo-3-fluoro- synthesis
- Product Name:Benzeneethanol, 4-bromo-3-fluoro-
- CAS Number:1331944-00-3
- Molecular formula:C8H8BrFO
- Molecular Weight:219.05
![4-BROMO-3-FLUOROPHENYLACETIC ACID](/CAS2/GIF/942282-40-8.gif)
942282-40-8
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$18.14/1g
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1331944-00-3
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Yield:1331944-00-3 89.8%
Reaction Conditions:
with borane-THF in tetrahydrofuran at 0 - 20; for 2 h;
Steps:
5.1; 291.1 Step 1: 2-(4-bromo-3-fluorophenyl)ethan-1-ol
To a solution of 2-(4-bromo-3-fluorophenyl)acetic acid (45.0 g,193 mmol)in THF (270 mL) was added BH 3.THF (1 M,386 mL)at 0 . Then the mixture was stirred at 20 for 2 hrs. Under cooling with ice, MeOH (250 mL) was dropwise added until there was no foaming in the system and the solvent was distilled off under reduced pressure. To the resulting reside, water (50.0mL) was added for extraction with EtOAc (1000.0 mL) . The combined organic phase was washed with brine (40.0 mL) , dried over Na 2SO 4, filtered and concentrated in vacuum. 2-(4-bromo-3-fluorophenyl)ethan-1-ol (38.0 g, 89.8%) was obtained. 1HNMR (400 MHz, CDCl 3-d) δ ppm 7.45 (t, J = 7.72 Hz,1 H) ,7.00 (dd, J = 9.48,1.76 Hz,1 H) ,6.86 -6.92 (m,1 H) ,3.82 (t, J = 6.50 Hz,2 H) ,2.80 (t, J = 6.50 Hz,2 H) ,2.03 (s,1 H) ; [M+H] + = 219.
References:
WO2022/12622,2022,A1 Location in patent:Page/Page column 141-142; 224
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942282-41-9
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![3-Fluoro-4-Bromoobenzyl Cyanide](/CAS2/GIF/499983-13-0.gif)
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127425-73-4
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