Benzenemethanamine, N-methylene- synthesis

4synthesis methods

Product Name:Benzenemethanamine, N-methylene-
CAS Number:4393-14-0
Molecular formula:C8H9N
Molecular Weight:119.16

2547-66-2 Synthesis

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Yield:-

Reaction Conditions:

with boron trifluoride diethyl ether complex in dichloromethane at 45; for 3 h;Inert atmosphere;

Steps:

166

A solution of 1,3,5-tribenzyl-1,3,5-triazinane (10.3 g, 28.81 mmol, 1.00 equiv) and BF3.Et2O (12.27 g, 86.43 mmol, 3.00 equiv) in DCM (100 mL) was stirred for 3h at 45 degrees C under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. This resulted in benzyl(methylidene)amine (11.5 g, 334.95%) as a yellow oil. LC-MS: (M+H)⁺ found: 119

References:

WO2022/76831,2022,A2 Location in patent:Page/Page column 722

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