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Benzenemethanol, a-ethynyl-4-fluoro- synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
1.2: 1 h / -78 - 20 °C / Inert atmosphere
2.1: potassium carbonate / methanol / 2 h / 20 °C

References:

Shi, Feng;Luo, Shi-Wei;Tao, Zhong-Lin;He, Long;Yu, Jie;Tu, Shu-Jiang;Gong, Liu-Zhu [Organic Letters,2011,vol. 13,# 17,p. 4680 - 4683]