Benzenepropanoic acid, 4-Methyl-, Methyl ester synthesis
- Product Name:Benzenepropanoic acid, 4-Methyl-, Methyl ester
- CAS Number:56955-36-3
- Molecular formula:C11H14O2
- Molecular Weight:178.23
67-56-1
738 suppliers
$9.00/25ml
1505-50-6
151 suppliers
$11.00/1g
56955-36-3
23 suppliers
$325.00/500mg
Yield:56955-36-3 73%
Reaction Conditions:
with sulfuric acid for 24 h;Reflux;
Steps:
General procedure for the synthesis of compounds 9-12 and 21-29
General procedure: After dissolving the carboxylic acid in the alcohol, three drops of H2SO4 95% were added to the solution and the mixture was refluxed for 24 h. The solvent was evaporated under reduced pressure and water was added to the crude mixture. The pH of the aqueous layer was adjusted to 7 adding drops of a saturated solution of NaHCO3 and brine was added in the mixture. The aqueous layer was extracted three times with ethyl acetate; the organic layer was dried over Na2SO4 and the solvent was evaporated under reduced pressure yielding the final compound. Further purification step was made when it was necessary.
References:
Allegretta, Giuseppe;Weidel, Elisabeth;Empting, Martin;Hartmann, Rolf W. [European Journal of Medicinal Chemistry,2015,vol. 90,p. 351 - 359]
20754-20-5
107 suppliers
$6.00/1g
56955-36-3
23 suppliers
$325.00/500mg
106-38-7
399 suppliers
$14.00/5g
158613-23-1
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inquiry
56955-36-3
23 suppliers
$325.00/500mg
292638-85-8
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inquiry
620-23-5
315 suppliers
$5.00/5g
56955-36-3
23 suppliers
$325.00/500mg
622-97-9
130 suppliers
$10.00/5mL
124-38-9
123 suppliers
$214.00/14L
18107-18-1
208 suppliers
$33.00/5g
56955-36-3
23 suppliers
$325.00/500mg
79443-97-3
16 suppliers
$495.45/5MG