Benzenesulfonamide, 2-amino-N-(2-hydroxyethyl)- synthesis

2synthesis methods

Product Name:Benzenesulfonamide, 2-amino-N-(2-hydroxyethyl)-
CAS Number:959336-90-4
Molecular formula:C8H12N2O3S
Molecular Weight:216.26

N-(2-hydroxyethyl)-2-nitrobenzenesulfonamide

18226-11-4
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Benzenesulfonamide, 2-amino-N-(2-hydroxyethyl)-

959336-90-4
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Yield:959336-90-4 80%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in methanol; under 750.075 Torr;

Steps:

08

N-(2-Hydroxyethyl)-2-nitrobenzene sulfonamide (1.25g, 5.08mmol) was dissolved in methanol (50ml) and placed under an atmosphere of nitrogen prior to the addition of 10% Pd/C (10 Wt%, 125mg) in one portion. The reaction was evacuated, placed under an atmosphere of hydrogen (1 bar) and stirred vigorously overnight. The reaction was filtered through celite and the filtrate was concentrated in vacuo to afford the named product (0.88g, 80%); LCMS R_t=2.05 min, m/z (ES+) 217 (M+H).

References:

WO2009/71947,2009,A2 Location in patent:Page/Page column 55-56

1694-92-4 Synthesis

1694-92-4
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$13.31/25G

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References