![](/CAS/GIF/199590-69-7.gif)
Benzenesulfonamide, 2-fluoro-4-methyl- (9CI) synthesis
- Product Name:Benzenesulfonamide, 2-fluoro-4-methyl- (9CI)
- CAS Number:199590-69-7
- Molecular formula:C7H8FNO2S
- Molecular Weight:189.21
![2-Fluoro-4-methylaniline](/CAS/GIF/452-80-2.gif)
452-80-2
265 suppliers
$6.00/1g
![Benzenesulfonamide, 2-fluoro-4-methyl- (9CI)](/CAS/GIF/199590-69-7.gif)
199590-69-7
17 suppliers
$45.00/100mg
Yield:199590-69-7 37%
Reaction Conditions:
Stage #1: 2-fluoro-4-methylanilinewith hydrogenchloride;sodium nitrite in water;acetic acid at -5;Cooling;
Stage #2: with sulfur dioxide;copper dichloride in water;acetic acid at -5; for 0.25 h;Cooling;
Stage #3: with ammonium hydroxide in 1,4-dioxane;water; for 0.5 h;Cooling;Reagent/catalyst;
References:
Drapier, Thomas;Geubelle, Pierre;Bouckaert, Charlotte;Nielsen, Lise;Laulumaa, Saara;Goffin, Eric;Dilly, Sébastien;Francotte, Pierre;Hanson, Julien;Pochet, Lionel;Kastrup, Jette Sandholm;Pirotte, Bernard [Journal of Medicinal Chemistry,2018,vol. 61,# 12,p. 5279 - 5291]