BenzenesulfonaMide, 4-(1-Methylethoxy)- synthesis
- Product Name:BenzenesulfonaMide, 4-(1-Methylethoxy)-
- CAS Number:100861-05-0
- Molecular formula:C9H13NO3S
- Molecular Weight:215.27
1576-43-8
125 suppliers
$11.00/1g
75-26-3
451 suppliers
$10.00/10g
100861-05-0
9 suppliers
$65.00/1g
Yield:100861-05-0 48%
Reaction Conditions:
with sodium hydroxide in water;N,N-dimethyl-formamide at 50;
Steps:
4.4-1 Step 1-4:
2-Bromopropane (106 mg, 0.87 mmol) was added into a solution of 4- hydroxybenzenesulfonamide (100 mg, 0.58 mmol) in aq. IN NaOH (1.2 mL) and DMF (5 mL). The mixture was stirred at 50 °C overnight. After cooling to room temperature, the mixture was diluted with EtOAc Π 0 mL") and washed with brine. The organic layers were dried over Na2S04, filtered, and concentrated. The residue was purified by Flash-Prep-HPLC ((IntelFlash-1): Column, CI 8; mobile phase, MeCN/H20, Detector, UV 254 nm) to give 4- isopropoxybenzenesulfonamide (4-1) (60 mg, 48%) as a yellow solid.
References:
WO2018/152171,2018,A1 Location in patent:Page/Page column 38; 39
98995-40-5
101 suppliers
$27.19/1g
100861-05-0
9 suppliers
$65.00/1g