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Benzenesulfonamide, 5-(2-aminoethyl)-2-methoxy- synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: 73 percent / CH2Cl2 / 0.5 h / Ambient temperature
2: 13.5 g / ClSO3H / CH2Cl2 / 2 h / Heating
3: conc. NH4OH / tetrahydrofuran / 0.5 h / Ambient temperature
4: aq. NaOH / methanol / 0.5 h / Ambient temperature

References:

Sakurai;Mitani;Hashimoto;Morikawa;Yasuda;Koshinaka;Kato;Ito [Chemical and Pharmaceutical Bulletin,1992,vol. 40,# 6,p. 1443 - 1451]