Benzenesulfonyl chloride, 4-(acetylamino)-3-bromo- synthesis
- Product Name:Benzenesulfonyl chloride, 4-(acetylamino)-3-bromo-
- CAS Number:88963-75-1
- Molecular formula:C8H7BrClNO3S
- Molecular Weight:312.57
614-76-6
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Yield:-
Reaction Conditions:
with chlorosulfonic acid at 0 - 80; for 4 h;Time;
Steps:
115.2 4-acetamido-3-bromobenzene-1-sulfonyl chloride
To a stirring of HSO3CI (24.1 g, 207 mmol, 4.4 eq) was added compound 123-2 (10.0 g, 46.7 mmol, 1.0 eq) at 0 °C. After addition complete, the reaction mixture was stirred at 80 °C for 4 hours. TLC showed the starting material was consumed. The reaction mixture was added to ice (300 g) and then warm up to 25 °C. The suspension was extracted with EA (3 *80 mL) to obtain the title compound 123-3 (12 g, crude).
References:
WO2019/40380,2019,A1 Location in patent:Paragraph 00440
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