BENZENESULFONYL CYANIDE synthesis

3synthesis methods

Product Name:BENZENESULFONYL CYANIDE
CAS Number:24224-99-5
Molecular formula:C7H5NO2S
Molecular Weight:167.19

BENZENESULFINIC ACID SODIUM SALT DIHYDRATE

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Yield: 93.8%

Reaction Conditions:

in dichloromethane;water

Steps:

R.1
Reference Example 1 In a 200 ml four-necked flask, 70 g of water, 2 g of methylene chloride and 32.0 g (0.16 mol.) of sodium benzenesulfinate dihydrate were charged, and then cooled to 3° C. Then, 10.7 g (0.17 mol.) of gaseous cyanogen chloride was introduced into the flask for about 15 minutes while keeping the internal temperature at 3 to 6° C. After introducing cyanogen chloride, the reaction mixture was stirred at 5° C. for 30 minutes and then the mixture was transferred into a separation funnel. The organic layer was separated, and 5 g of methylene chloride was added to the aqueous layer to extract benezenesulfonyl cyanide, and then the extract and the organic layer were combined, dried over magnesium sulfate, and then methylene chloride was removed by distillation under reduced pressure to obtain 24.8 g (0.15 mol.) of benezenesulfonyl cyanide (yield: 93.8%).

References:

Kuraray Co., Ltd. US6232473, 2001, B1

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References

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References