ChemicalBook CAS DataBase List Benzenesulfonyl fluoride, 3-chloro-

Benzenesulfonyl fluoride, 3-chloro- synthesis

6synthesis methods

Product Name:Benzenesulfonyl fluoride, 3-chloro-
CAS Number:10116-74-2
Molecular formula:C6H4ClFO2S
Molecular Weight:194.61

2888-06-4 Synthesis

2888-06-4
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10116-74-2
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Yield:10116-74-2 86%

Reaction Conditions:

with potassium fluoride in 1,4-dioxane; for 4 h;Heating / reflux;

Steps:

8

Preparation 8 3-Chloro-benzenesulfonyl fluoride; The synthetic procedure described in this Preparation was carried out according to the process shown in Scheme I.SCHEME IPotassium fluoride (2.28 g, 39.4 mmol) was added to a solution of 3-chlorosulfonylchloride (2.08 g, 9.855 mmol) in 1,4-dioxane (50 mL) under nitrogen atmosphere. The reaction mixture was heated at reflux for 4 hours, then cooled to 0-5⁰C, and ice-water was added. The resulting mixture was extracted with EtOAc. The combined organic extracts were washed with brine, dried over Na₂SO₄, filtered and evaporated under reduced pressure. The residue was purified via flash chromatography (hexane/EtOAc, 9/1) to give 1.64 g (86% yield) of 3- chlorosulfonylfluoride as a colorless oil.

References:

WO2008/55847,2008,A1 Location in patent:Page/Page column 65

108-42-9 Synthesis