Benzo[b]thiophene, 7-nitro- synthesis

9synthesis methods

Product Name:Benzo[b]thiophene, 7-nitro-
CAS Number:17511-54-5
Molecular formula:C8H5NO2S
Molecular Weight:179.2

90407-22-0 Synthesis

7-Nitrobenzo[b]thiophene-2-carboxylic acid

90407-22-0
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17511-54-5
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Yield:17511-54-5 90%

Reaction Conditions:

with copper(I) oxide in N,N-dimethyl-formamide at 120; for 2 h;

Steps:

3

The above 7-nitro-benzothiophene-2 carboxylic acid (2.3g), DMF (20ml) and cuprous oxide (0.3g) were mixed and stirred. The oil bath was heated at 120 ° C for 2 hours for reaction and sampling. The basic reaction was complete and reduced The solvent was distilled off under reduced pressure, the residue was added with water, stirred with ethyl acetate, and the liquid was separated. The aqueous phase was extracted with ethyl acetate, the organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, filtered with suction, and spin-dried to obtain 7-nitro Benzothiophene (Compound 6), yellow solid 1.61 g, 90% yield.

References:

CN111100110,2020,A Location in patent:Paragraph 0065; 0069-0070

34084-89-4 Synthesis