ChemicalBook CAS DataBase List BENZO[D]OXAZOL-2-YLMETHANAMINE

BENZO[D]OXAZOL-2-YLMETHANAMINE synthesis

5synthesis methods

Product Name:BENZO[D]OXAZOL-2-YLMETHANAMINE
CAS Number:101333-98-6
Molecular formula:C8H8N2O
Molecular Weight:148.16

Carbamic acid, N-(2-benzoxazolylmethyl)-, phenylmethyl ester

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Yield:-

Reaction Conditions:

with ammonium hydroxide;palladium 10% on activated carbon;hydrogen in methanol at 25; under 775.743 Torr; for 2 h;

Steps:

Step 3.1,3-Benzoxazol-2-ylmethanamine

A mixture of benzyl N-(1,3-benzoxazol-2-ylmethyl)carbamate (0.5 g, 1.77 mmol, 1 eq), Pd/C (500 mg, 10% purity) in MeOH (50 mL), NH₃·H₂O (2 mL) was degassed and purged with H₂ (3x), and then the mixture was stirred at 25°C for 2 h under H₂ (15 psi) atmosphere. The resulting mixture was then filtered and the filtrate was concentrated to afford the title compound (235 mg, crude) as a red solid

References:

WO2022/31928,2022,A1 Location in patent:Page/Page column 75

41014-43-1 Synthesis