Benzofuran, 3-(chloromethyl)- synthesis
- Product Name:Benzofuran, 3-(chloromethyl)-
- CAS Number:67713-99-9
- Molecular formula:C9H7ClO
- Molecular Weight:166.6
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Yield:67713-99-9 78%
Reaction Conditions:
with phosphorus pentachloride in dichloromethane at 30; for 2 h;
Steps:
47
Into a lOO-mL round-bottom flask, was placed l-benzofuran-3-ylmethanol (2 g, 13.50 mmol, 1.00 eq.), dichloromethane (40 mL), PCIs (3.65 g, 17.53 mmol, 1.30 eq.). The resulting solution was stirred for 2 h at 30 °C. The resulting mixture was washed with sodium chloride. The resulting solution was extracted with of dichloromethane and the organic layers combined and dried over anhydrous sodium sulfate and concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate:petroleum ether (1 :100). This resulted in 1.76 g (78%) of 3-(chloromethyl)-l-benzofuran as yellow oil.
References:
WO2019/99582,2019,A1 Location in patent:Paragraph 0399; 0400
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