Benzoic acid, 2-Mercapto-5-nitro- synthesis

Yield:-

Steps:

Multi-step reaction with 3 steps
1: 1,4-diaza-bicyclo[2.2.2]octane / N,N-dimethyl-formamide / 3 h / Inert atmosphere
2: diphenylether / 0.02 h / 250 °C / Microwave irradiation; Inert atmosphere
3: sodium hydroxide / water; methanol / 16 h / Inert atmosphere; Reflux

References:

Castelli, Riccardo;Scalvini, Laura;Vacondio, Federica;Lodola, Alessio;Anselmi, Mattia;Vezzosi, Stefano;Carmi, Caterina;Bassi, Michele;Ferlenghi, Francesca;Rivara, Silvia;M?ller, Ingvar R.;Rand, Kasper D.;Daglian, Jennifer;Wei, Don;Dotsey, Emmanuel Y.;Ahmed, Faizy;Jung, Kwang-Mook;Stella, Nephi;Singh, Simar;Mor, Marco;Piomelli, Daniele [Journal of Medicinal Chemistry,2020,vol. 63,# 3,p. 1261 - 1280]