Benzoic acid, 3-bromo-5-chloro-, hydrazide synthesis

3synthesis methods

Product Name:Benzoic acid, 3-bromo-5-chloro-, hydrazide
CAS Number:1095274-56-8
Molecular formula:C7H6BrClN2O
Molecular Weight:249.49

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Benzoic acid, 3-bromo-5-chloro-, hydrazide

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Yield:-

Reaction Conditions:

with hydrazine in ethanol at 80;

Steps:

29

Ethyl 3-bromo-5-chlorobenzoate (D28, 2.8 g, 10.63 mmol) was dissolved in ethanol (20 ml.) at room temperature. Hydrazine hydrate (10.34 ml_, 213 mmol) was added and the reaction was stirred at 80⁰C overnight. Solvents were removed in vacuo and then azeotroped with toluene to give the title compound.LC/MS (ES+ve): [M+H]⁺ at m/z 249, 251 , 253 (C₇H₆BrCIN₂O requires [M+H]⁺ at m/z 249, 251 , 253)

References:

WO2009/819,2008,A1 Location in patent:Page/Page column 50

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References

42860-02-6 Synthesis

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References