ChemicalBook CAS DataBase List Benzoic acid, 4-chloro-2-formyl-

Benzoic acid, 4-chloro-2-formyl- synthesis

6synthesis methods

Product Name:Benzoic acid, 4-chloro-2-formyl-
CAS Number:4657-56-1
Molecular formula:C8H5ClO3
Molecular Weight:184.58

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Yield: 85%

Reaction Conditions:

with water;lithium hydroxide in methanol at 20;

Steps:

199.1.1 Step 1: Preparation of 5-chloro-2-(morpholine-4-carbonyl)benzaldehyde
Step 1: Preparation of 5-chloro-2-(morpholine-4-carbonyl)benzaldehyde [00473] Part 1. A 100-mL round-bottom flask was charged with methyl 4-chloro-2- formylbenzoate (1.40 g, 7.05 mmol, 1.00 equiv), LiOH (339 mg, 14.15 mmol, 2.00 equiv), methanol (10 mL), and 0 (1 mL). The resulting solution was stirred overnight at room temperature and adjusted to PH=4 with hydrogen chloride (IN). The solids were collected by filtration to provide 1.10 g (85% yield) of 4-chloro-2-formylbenzoic acid as a white solid. LCMS (ESI, m/z): 183 [M-H]^".

References:

ABIDE THERAPEUTICS;THE SCRIPPS RESEARCH INSTITUTE;CISAR, Justin, S.;GRICE, Cheryl, A.;JONES, Todd, K.;WANG, Dong-Hui;WEBER, Olivia;CRAVATT, Benjamin, F.;NIPHAKIS, Micah, J.;COGNETTA, Armand;CHANG, Jae Won WO2013/142307, 2013, A1 Location in patent:Paragraph 00473

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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References

54109-03-4 Synthesis

54109-03-4
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References

19641-29-3
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$38.00/100mg

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References

65399-05-5 Synthesis

65399-05-5
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$37.00/100mg

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References