ChemicalBook CAS DataBase List Benzomorpholine

Benzomorpholine synthesis

13synthesis methods

Product Name:Benzomorpholine
CAS Number:5735-53-5
Molecular formula:C8H9NO
Molecular Weight:135.16

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Yield: 88%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen;toluene-4-sulfonic acid in ethanol at 50; under 37503.8 Torr; for 2 h;

Steps:

1.ii
In step (ii), intermediate c was reduced and cyclised to give the following fuel additive e Specifically, 2-(2-nitrophenoxy)acetonitrile (2.0 g, 11 mmol), //TSA (50 mg), 10 % Pd/C (100 mg) were stirred in ethanol (35 ml) under 50 bar at 50 °C for 2 hours. The reaction mixture was filtered, the solvent was evaporated, the residue was taken up into diethyl ether and filtered to remove solids. The solvent was removed in vacuo to give 1.34 g (88 % yield) of fuel additive e as a clear brown oil.

References:

BP OIL INTERNATIONAL LIMITED;FILIP, Sorin, Vasile WO2019/129591, 2019, A1 Location in patent:Page/Page column 33