Benzothiazole, 4-chloro-2-methoxy- (9CI) synthesis
- Product Name:Benzothiazole, 4-chloro-2-methoxy- (9CI)
- CAS Number:73443-77-3
- Molecular formula:C8H6ClNOS
- Molecular Weight:199.6573
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Yield:73443-77-3 99.8%
Reaction Conditions:
with sodium hydroxide in methanol;toluene;
Steps:
4 EXAMPLE 4
EXAMPLE 4 A mixture (20.87 g, 0.1 mole) of 2-bromo-4-chlorobenzothiazole and 2,4-dichlorobenzothiazole and a 48.5% aqueous sodium hydroxide solution (17.28 g, 0.21 mole) were added to toluene (150 c.c.), and then methanol (16.12 g, 0.5 mole) was added dropwise thereto at room temperature. After the addition was finished, the reaction solution was heated to 50° C. and maintained at 50° C. for 4 hours. After cooling, the toluene layer was washed three times with water, and the solvent was removed under reduced pressure to obtain 19.92 g of 2-methoxy-4-chlorobenzothiazole as a pale yellow viscous liquid (solidified after cooling). Yield 99.8%, purity 96.0%, m.p. 54°-56° C.
References:
US4293702,1981,A
3622-40-0
84 suppliers
$120.00/100mg
73443-77-3
7 suppliers
inquiry
3622-30-8
124 suppliers
$70.00/1g
73443-77-3
7 suppliers
inquiry