BENZOXAZOLE, 2-CHLORO-5-NITRO- synthesis
- Product Name:BENZOXAZOLE, 2-CHLORO-5-NITRO-
- CAS Number:54120-91-1
- Molecular formula:C7H3ClN2O3
- Molecular Weight:198.56
22876-21-7
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54120-91-1
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Yield:54120-91-1 4.4 g
Reaction Conditions:
with thionyl chloride;N,N-dimethyl-formamide at 65; for 1 h;
Steps:
2-Chloro-5-nitrobenzo[d]oxazole
o a suspension of 5-nitrobenzo[d]oxazole-2-thiol (5.9 g, 30 mmol) in thionyl chloride (54.7 mL, 751 mmol) DMF (0.04 mL, 0.456 mmol) was added. The mixture was heated to 65°C and stirred for 1 h. The mixture was cooled to rt and concentrated. The residue was suspended in toluene (30 mL) and the solvent was again evaporated. The residue was then taken up in DCM (25 mL) and purified by CC eluting with heptane:EA 4:1 to give the title compound (4.4 g) as a beige solid; LC-MS: tR= 0.78 min; [M+H]+= not detectable;1H NMR (400 MHz, CDCI3) δ: 8.61 (d, J = 2.3 Hz, 1 H), 8.38 (dd, J, = 2.3 Hz, J2= 9.0 Hz, 1 H), 7.68 (d, J = 9.0 Hz, 1 H).
References:
WO2016/207785,2016,A1 Location in patent:Page/Page column 44
22876-21-7
69 suppliers
inquiry
54120-91-1
47 suppliers
$52.50/250mg
99-57-0
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$22.00/25g
54120-91-1
47 suppliers
$52.50/250mg
51-28-5
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$14.14/5gm:
54120-91-1
47 suppliers
$52.50/250mg